MERIDIA
This information is intended for U.S. residents only. (sibutramine hydrochloride monohydrate) INDICATIONS AND USAGE DRUG ABUSE AND DEPENDENCE DOSAGE AND ADMINISTRATION ... concentrations do not warrant dosage adjustment in patients with. mild to moderate hepatic impairment. MERIDIA should ...
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MERIDIA (sibutramine hydrochloride monohydrate) Capsules MERIDIA (sibutramine hydrochloride monohydrate) is an orally administered agent for the treatment of obesity. Chemically, the active ... ... concentrations do not warrant dosage adjustment in patients with mild to moderate. hepatic impairment. MERIDIA should ...
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SIBUTRAMINE
B. PROTEIN BINDING 1. In vitro protein binding of sibutramine and its two desmethyl metabolites, M1 and M2 is 97%, 94%, and 94%, respectively (Prod Info Meridia(R), 1997). 8.2.2 DISTRIBUTION ... ... Plasma concentrations of the two active metabolites reached steady-state within 4 days of dosing (Prod Info Meridia(R), ...
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SIBUTRAMINE
(1) ADULT DOSAGE AND ADMINISTRATION: The dose, concentration in dosing solutions, and infusion rate of fosphenytoin are expressed as phenytoin sodium equivalents. ... Do not obtain serum phenytoin concentrations until at least 2 hours after infusion is complete to allow for conversion ... (1) ECG; plasma concentrations. 3. BRETYLIUM ...
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